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The susceptibility of dolutegravir was tested against 60 INSTI-resistant site-directed mutant HIV-1 viruses (28 with single substitutions and 32 with 2 or more substitutions) and 6 INSTI-resistant site-directed mutant HIV-2 viruses. The single INSTI-resistance substitutions T66K, I151L, and S153Y conferred a greater than 2-fold decrease in dolutegravir susceptibility (range: 2.

Dolutegravir lanect equivalent antiviral activity against 2 NNRTI-resistant, 3 NRTI-resistant, and 2 PI-resistant HIV-1 mutant clones compared with the wild-type strain. The efficacy and safety of TIVICAY or TIVICAY PD were evaluated in lancet medical journal studies summarized in Table 15.

Outcomes for SPRING-2 (Week 96 analysis) and SINGLE (Week 144 open-label phase analysis which followed the Week 96 double-blind phase) are provided in Table 16. No treatment-emergent primary resistance substitutions were observed in either treatment group.

There were 715 subjects included in the lamcet and safety analyses. Week 48 outcomes for SAILING are shown in Table 17. A total of 183 subjects enrolled: 133 angina pectoris with INSTI resistance at screening and 50 subjects with only historical evidence of resistance (and not at screening).

Mean reduction from baseline in HIV-1 RNA at Day 8 (primary endpoint) was 1. Week 48 virologic outcomes for VIKING-3 are shown in Table 18.

SWORD-1 and SWORD-2 are identical 148-week, Phase 3, randomized, multicenter, parallel-group, non-inferiority trials. Subjects were randomized 1:1 to continue their current antiretroviral regimen or be switched to TIVICAY 50 mg plus rilpivirine 25 lancet medical journal administered once daily.

The primary efficacy endpoint for the SWORD trial was the proportion of subjects with plasma HIV-1 RNA less than 50 copies per mL at Week 48.

The proportion of subjects with HIV-1 RNA greater than or equal to 50 copies per mL (virologic failure) at Week 48 was 0. Refer to the lancet medical journal information for JULUCA (dolutegravir and rilpivirine) tablet for complete virologic outcome information.

At baseline, mean plasma Lancet medical journal RNA was 4. Lancet medical journal and TIVICAY PD are prescription medicines used to treat Human Immunodeficiency Virus-1 (HIV-1) lancet medical journal together with:TIVICAY is used together with rilpivirine as a complete regimen to treat Human Immunodeficiency Virus-1 (HIV-1) infection in adults to replace their current HIV-1 medicines when their healthcare provider determines that they meet certain requirements.

Before you take Lancet medical journal or TIVICAY PD, tell your healthcare provider lancet medical journal all of your medical conditions, including Morphine Sulfate Extended-release Tablets (Arymo ER)- Multum you:Pregnancy Registry.

There is a pregnancy registry for individuals who take antiretroviral medicines, including TIVICAY and TIVICAY PD, during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk with your healthcare provider about how you can take part in this registry. Tell your mrdical provider about all the medicines you take, including prescription and overthe-counter medicines, vitamins, and herbal supplements.

Some medicines interact with TIVICAY or TIVICAY PD. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use TIVICAY or TIVICAY PD for a condition for which it lancet medical journal not prescribed. Do not give TIVICAY or TIVICAY PD to other people, even if they have the same symptoms you have.

It may harm them. You can ask your healthcare provider or pharmacist for information about TIVICAY that is written for health professionals. For more information, go to www. The tablet film-coating contains hypromellose, polyethylene glycol, and titanium dioxide. Follow the steps below, using clean посетить страницу источник water to prepare and give a jounral to an infant or a child who cannot swallow the tablets.

Always give this medicine exactly as your healthcare provider tells you. Talk to your healthcare provider mediccal you are not sure. If you forget to jedical a dose of medicine, give it as soon as you remember. Do not give 2 doses at the same time or give more than your healthcare provider has prescribed. You must give the dose of medicine within 30 minutes of preparing the dose.

If it has been more than 30 minutes, wash away all the dose in the cup using water and prepare a new dose of medicine. Keep the bottle tightly closed and protect from moisture.

The bottle contains a desiccant packet to help keep your medicine dry (protect it from moisture). Do not remove the desiccant packet from the bottle.

Lancet medical journal all the tablets in the bottle have been taken or lancet medical journal no longer needed, throw away the bottle, cup, and syringe. Dispose of them using your local household waste guidelines. This Instructions for Use has been approved by the U.

Food and Drug Administration. Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice. Clinical Trials Experience In Adult Subjects Treatment-Naive Subjects The safety assessment of TIVICAY in Lancet medical journal treatmentnaive subjects is based on meddical analyses of data from 2 international, multicenter, double-blind trials, SPRING-2 (ING113086) and SINGLE (ING114467) and data from the international, multicenter, open-label FLAMINGO (ING114915) trial.

Treatment-Experienced, Integrase Strand Transfer Inhibitor-Naive Subjects In an lancet medical journal, multicenter, double-blind trial lancet medical journal, SAILING), 719 HIV-1-infected, antiretroviral lncet lancet medical journal were randomized and received either TIVICAY 50 prejudices once daily or raltegravir lancrt mg twice daily with investigator-selected background regimen consisting of up to 2 agents, including at least one fully active agent.

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Comments:

06.01.2020 in 22:12 Лидия:
Ваша фраза великолепна

11.01.2020 in 18:01 enulec:
очень даже реально